Bowl-Shaped Catalysts for Site-Selective C-H Functionalization
Abstract
For some time, we have been interested in developing chiral dirhodium catalysts for site-selective C-H functionalization by means of rhodium carbene-induced C-H insertion.1,2 This presentation will describe a series of new bowl-shaped catalysts, which are capable of distinguishing between very similar C-H bonds in a highly selective manner. This approach for C-H functionalization offers new strategic opportunities to access natural products and targets of pharmaceutical interest, and some of our recent accomplishments in these areas will be described.
References
- Dirhodium Tetracarboxylates: Privileged Catalysts for Selective Intermolecular C-H Functionalization, Davies, H. M. L.; Liao K. Nature Rev. Chem. 2019, 3, 347-360.
- Finding Opportunities from Surprises and Failures. Development of Rhodium-Stabilized Donor/Acceptor Carbenes and their Application to Catalyst-Controlled C-H Functionalization, Davies, H. M L. J. Org. Chem. 2019, 84, 12722-12745.
About School research seminars
Seminars cover all aspects of chemistry and molecular biosciences and are delivered by visiting national and international academics. PhD completion seminars are also incorporated into the program.
Seminars are usually held in person and via zoom. All are welcome to attend.
Contacts
- Chemistry: Dr Rowan Young, Dr David Cantillo
- Molecular Biosciences: Dr Mathew Jones