A scope of synthetic approaches for the development of Mitochondria targeting Ru(II)/Ir(III)/Re(I) based mono metallic and bimetallic complexes for cancer therapy

Title:  A scope of synthetic approaches for the development of Mitochondria targeting Ru(II)/Ir(III)/Re(I) based mono metallic and bimetallic complexes for cancer therapy                                                        

 Speaker:  Dr Priyankar Paira, Department of Chemistry, School of Advanced Sciences, VIT, Vellore-632014, Tamilnadu, India

Abstract: Chemotherapy is the most prevalent traditional cancer therapy but it lacks tumor specificity and thus it renders normal cells at risk. Therefore, considerable attention should be given on the design and synthesis of new metal complexes by following approaches including (i) selectivity in cancer cell by non-covalent modes of DNA interaction (ii) mitochondria specificity (iii) development of various photo-toxic agents as these produce reactive oxygen species (ROS) at the photo-exposed cancer cells leaving the unexposed healthy cells minimally affected. (iv) “Theranostic”, which includes simultaneous diagnostic and therapeutic functions in a single system improving the outcome of a disease state. With respect to therapeutic regimes, improved treatment effect is achieved by effective localization at the tumor specific sites of the therapeutic agents whereas from diagnostic aspect imaging agents along with therapeutic agents combined with biomarkers (tumor specific markers) are carried from one system to another enabling them to differentiate the tumor cells from normal cells. In continuation of our present work on anticancer complexes, we have introduced the convenient and effective synthetic approaches for designing the monometallic and bimetallic Ru(II)/Ir(III)/Re(I) complexes which can address all three approaches. The operational simplicity, good yield, ease of isolation of the products and high chemoselectivity will be the main advantages of these methods (Fig. 1).1, 2