Protein
Electrochemistry
Electron transfer is fundamental to many biological
processes. Direct electron transfer between an electrochemical working
electrode and a redox active protein enables important mechanistic information
to be determined. We are currently looking at the direct electrochemistry
of several different types of redox active proteins including:
-
Mo-containing oxotransferases
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cytochromes P450 (human and bacterial)
-
components of sulfur oxidising multi-enzyme complexes
The broken line is the cyclic voltammogram of the enzyme xanthine dehydrogenase
(R. capsulatus)
The unbroken line shows the enhancement in anodic current upon addition
of xanthine (see K. F. Aguey-Zinsou, P. V. Bernhardt and S. Leimkuehler,
J. Am. Chem. Soc., 2003, 125, 15352)