Project duration:

Number of students for this project:

4-6 weeks



Short peptides (sPEPs)that are encoded by short Open Reading Frames (sORFs) are surprisingly common in eukaryote genomes. Recently, a mutation in a sPEP has been associated with a genetic disorder. Recent bioinformatic and ribosomal footprinting studies have identified several thousand sORFs with coding potential and several sPEPs have been identified by mass spectrometry.  However, their role in cellular functions remains to be determined. You will identify and characterize sPEPs using bioinformatic tools, proteomics (mass spec) and cell biology. You will help to determine the contribution of sPEPs to the human proteome, and  provide insights into their roles.  This project will involve analysing raw proteomic (mass spec) data. 

Suitable academic background:

Knowledge of molecular and cell biology methods.  Bioinformatics and computational skills would be an advantage. 

Primary Supervisor:


Joe Rothnagel

Further info: